Historically, Mukono was one of the centres of civilization in Uganda. At the advent of the colonization in Africa, big Christian missions, hospitals, schools and colleges were established in Mukono.

In 1890, Bishop Tucker of the Church Missionary Society (CMS) from England established the Christian Mission and a hospital on Mukono hill. He also established the Bishop Tucker Theological College, which is now the Uganda Christian University (UCU).

In 1902, Bishop Henry Hanlon of the Catholic Mill Hill Missionaries from England established the famous Namilyango College.

In 1908, Uganda was declared “the Pearl of Africa” at Mukono on the hill which is known by the locals as “Ggulu” – “Heaven”. One early morning in 1908, when Sir Wilson Churchill, former British prime minister was on a tour of this part of Africa, he woke up to a very clear morning African weather.

He stood on that hill and looked eastwards. He saw undulating hills of Kyaggwe County, valleys, green trees and grass, which he had not seen anywhere else in Africa and he declared, “This is really the Pearl of Africa.” Mukono is the main gateway to Uganda from the east African coast.